rs118109628 - TMEM158 - U3

Magnitude 4.5 · 1 study on file

Reported associations

• Genomic Analysis Identifies New Loci Associated With Motor Complications in Parkinson's Disease - Unknown journal (n.d.) · Unknown authors · PubMed 32733355

  ABSTRACT: Background: Parkinson's disease (PD) is a common neurodegenerative disorder, characterized by a clinical symptomatology involving both motor and non-motor symptoms. Motor complications associated with long-term dopaminergic treatment include motor fluctuations and levodopa-induced dyskinesia (LID), which may have a major impact on the quality of life. The clinical features and onset time of motor complications in the disease course are heterogeneous, and the etiology remains unknown. Objective: We aimed to identify genomic variants associated with the development of motor fluctuations and LID at 5 years after the onset of PD. Methods: Genomic data were obtained using Affymetrix Axiom KORV1.1 array, including an imputation genome-wide association study (GWAS) grid and other GWAS l

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