Expressive

rs118106133 - UNGP1 - HNRNPA1L3

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484

    ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • high-sensitivity C-reactive protein (hsCRP) Moderate

    T allele carriers have elevated baseline CRP, an inflammatory marker associated with increased cardiovascular disease risk

    Annual hsCRP measurement; discuss elevation (>3 mg/L) with healthcare provider

Diet

  • anti-inflammatory foods (leafy greens, fatty fish, berries) Moderate

    Dietary modification is a primary management approach for elevated CRP in individuals with genetic predisposition to systemic inflammation

    Include fatty fish 2-3 times weekly and colorful vegetables with each meal

Exercise

  • regular aerobic exercise Moderate

    Aerobic activity is an evidence-supported lifestyle intervention for reducing elevated CRP and cardiovascular risk

    150 minutes moderate-intensity aerobic exercise per week

Screening

  • cardiovascular risk assessment Moderate

    Elevated CRP is an independent cardiovascular risk marker requiring integrated assessment to quantify total risk burden