rs118104476 - AIFM1P1 - MALRD1
Magnitude 4.5 · 1 study on file
Reported associations
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A genome-wide association study of asthma hospitalizations in adults - Unknown journal (n.d.) · Unknown authors · PubMed 32890573
ABSTRACT: Background: Little is known about genetic determinants of severe asthma exacerbations. Objectives: We aimed to identify genetic variants associated with asthma hospitalizations. Methods: Genome-wide association study of asthma hospitalizations in 34,167 white British adults with asthma, of whom 1,658 (cases) had at least one asthma-related hospitalization. This analysis was conducted using logistic regression under an additive genetic model, adjusting for age, sex, body mass index, smoking status, and the first five principal components derived from genotypic data. We then analyzed data from two cohorts of Latino children and adolescents for replication and conducted quantitative trait locus and functional annotation analyses. Results: At the chromosome 6p21.3 locus, the single n
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic risk for asthma exacerbations Moderate
Variant rs118104476 is associated with 1.64-fold increased risk of asthma exacerbations requiring hospitalization
Lifestyle
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respiratory irritants and air pollution Moderate
Environmental triggers can precipitate asthma exacerbations; genetic variant increases hospitalization risk from exacerbations
Minimize exposure to smoke, pollution, strong chemicals, and known personal allergens
Screening
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asthma symptoms and triggers Moderate
Genetic risk increases asthma exacerbation severity; proactive symptom tracking and trigger avoidance reduces hospitalization risk
Track respiratory symptoms and potential triggers regularly