rs11809289 - KIRREL1 - SMIM42

Magnitude 2.2 · 1 study on file

Reported associations

• Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits - Unknown journal (n.d.) · Unknown authors · PubMed 33623009

  ABSTRACT: Clinical laboratory tests play a pivotal role in medical decision making, but little is known about their genetic variability between populations. We report a genome-wide association study with 45 clinically relevant traits from the population of Qatar using a whole genome sequencing approach in a discovery set of 6218 individuals and replication in 7768 subjects. Trait heritability is more similar between Qatari and European populations (r = 0.81) than with Africans (r = 0.44). We identify 281 distinct variant-trait-associations at genome wide significance that replicate known associations. Allele frequencies for replicated loci show higher correlations with European (r = 0.94) than with African (r = 0.85) or Japanese (r = 0.80) populations. We find differenc

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