Expressive

rs118091174 - HPS6 - LDB1

Magnitude 2.2 · 1 study on file

Reported associations

  • A genetic map of human metabolism across the allele frequency spectrum - Unknown journal (n.d.) · Unknown authors · PubMed 41044249

    ABSTRACT: Genetic studies of human metabolism have been limited in scale and allelic breadth. Here we provide a data-driven map of the genetic regulation of circulating small molecules and lipoprotein characteristics (249 traits) measured using proton nuclear magnetic resonance spectroscopy across the allele frequency spectrum in ~450,000 individuals. Trans-ancestral meta-analyses identify 29,824 locus-metabolite associations mapping to 753 regions with effects largely consistent between men and women and large ancestral groups represented in UK Biobank. We observe and classify extreme genetic pleiotropy, identify regulators of lipid metabolism, and assign effector genes at >100 loci through rare-to-common allelic series. We propose roles for genes less established in metabolic control (

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • VLDL triglyceride levels and lipid panel Moderate

    This variant is associated with elevated VLDL triglyceride percentage; monitoring baseline and response to lifestyle changes can guide management and assess cardiovascular risk.

    Check lipid panel including VLDL triglycerides at baseline and annually if initial levels elevated.

Diet

  • refined carbohydrates and added sugars Moderate

    Refined carbohydrates and added sugars increase hepatic triglyceride synthesis, particularly affecting VLDL production; this variant associates with elevated VLDL triglyceride percentage.

    Limit refined grains, sugary beverages, and added sugars to less than 5-10% of daily calories.

Exercise

  • regular aerobic exercise Moderate

    Aerobic exercise increases triglyceride catabolism and reduces hepatic VLDL production; those with genetic predisposition to elevated VLDL particularly benefit from regular activity.

    Aim for at least 150 minutes of moderate-intensity aerobic exercise per week or 75 minutes vigorous-intensity.

Supplements

  • omega-3 fatty acids Moderate

    Omega-3 polyunsaturated fatty acids (EPA and DHA) reduce triglyceride synthesis and improve triglyceride clearance; beneficial for individuals with elevated VLDL.

    Consider 1-3 grams per day EPA+DHA from fish or high-quality supplement; discuss with doctor about appropriate dosage.