rs11808336 - FGGY
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-Wide Meta-analysis of Variant-by-Diuretic Interactions as Modulators of Lipid Traits in Persons of European and African Ancestry - Unknown journal (n.d.) · Unknown authors · PubMed 31806883
ABSTRACT: Hypertension (HTN) is a significant risk factor for cardiovascular morbidity and mortality. Metabolic abnormalities, including adverse cholesterol and triglycerides (TG) profiles, are frequent comorbid findings with HTN and contribute to cardiovascular disease. Diuretics, which are used to treat HTN and heart failure, have been associated with worsening of fasting lipid concentrations. Genome-wide meta-analyses with 39,710 European-ancestry (EA) individuals and 9,925 African-ancestry (AA) individuals were performed to identify genetic variants that modify the effect of loop or thiazide diuretic use on blood lipid concentrations. Both longitudinal and cross-sectional data were used to compute cohort-specific interaction results, which were then combined through meta-analysis in ea
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Drug interactions
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triglycerides if taking loop diuretics Moderate
rs11808336 (FGGY) modifies triglyceride response to loop diuretics; FGGY affects expression in metabolically active liver and adipose tissue
annual fasting lipid panel while on loop diuretics