rs11808092 - EVI5

Magnitude 2.0 · 1 study on file

Reported associations

• Genetic loci for Epstein-Barr virus nuclear antigen-1 are associated with risk of multiple sclerosis. - Multiple sclerosis (Houndmills, Basingstoke, England) (2018) · Zhou Y, Zhu G, Charlesworth JC, Simpson S, Rubicz R, Göring HH, Patsopoulos NA, Laverty C, Wu F, Henders A, Ellis JJ, van der Mei I, Montgomery GW, Blangero J, Curran JE, Johnson MP, Martin NG, Nyholt DR, Taylor BV · PubMed 26819262

  Infection with the Epstein-Barr virus (EBV) is associated with an increased risk of multiple sclerosis (MS). We sought genetic loci influencing EBV nuclear antigen-1 (EBNA-1) IgG titers and hypothesized that they may play a role in MS risk. We performed a genome-wide association study (GWAS) of anti-EBNA-1 IgG titers in 3599 individuals from an unselected twin family cohort, followed by a meta-analysis with data from an independent EBNA-1 GWAS. We then examined the shared polygenic risk between the EBNA-1 GWAS (effective sample size (N ) = 5555) and a large MS GWAS (N = 15,231). We identified one locus of strong association within the human leukocyte antigen (HLA) region, of which the most significantly associated genotyped single nucleotide polymorphism (SNP) was rs2516049 (p = 

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