Expressive

rs118067990 - C16orf87

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association study of circulating levels of glucagon during an oral glucose tolerance test - Unknown journal (n.d.) · Unknown authors · PubMed 33407418

    ABSTRACT: Background In order to explore the pathophysiology underlying type 2 diabetes we examined the impact of gene variants associated with type 2 diabetes on circulating levels of glucagon during an oral glucose tolerance test (OGTT). Furthermore, we performed a genome-wide association study (GWAS) aiming to identify novel genomic loci affecting plasma glucagon levels. Methods Plasma levels of glucagon were examined in samples obtained at three time points during an OGTT; 0, 30 and 120 min, in two separate cohorts with a total of up to 1899 individuals. Cross-sectional analyses were performed separately in the two cohorts and the results were combined in a meta-analysis. Results A known type 2 diabetes variant in EYA2 was significantly associated with higher plasma glucagon level at

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • reduce refined carbohydrates and added sugars Moderate

    impaired glucagon suppression indicates glucose dysregulation; refined carbohydrates cause rapid glucose spikes that stress already-compromised beta cell function

    limit refined grains, sugary beverages, processed foods; prioritize whole grains, legumes, and non-starchy vegetables

    • GWAS_CATALOG:33407418

Exercise

  • regular aerobic physical activity Moderate

    impaired glucagon suppression indicates reduced insulin sensitivity; aerobic exercise improves insulin sensitivity and beta cell function

    150 minutes of moderate-intensity aerobic activity weekly

    • GWAS_CATALOG:33407418

Screening

  • glucose tolerance and beta cell function Moderate

    variant associated with impaired glucagon suppression during OGTT, indicating possible beta cell dysfunction and metabolic stress

    periodic HbA1c and fasting glucose testing; consider OGTT if metabolic concerns arise

    • GWAS_CATALOG:33407418