Expressive

rs118066617 - CARS2

Magnitude 4.5 · 1 study on file

Reported associations

  • Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449

    ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • CARS2 rs118066617 variant and vitamin D status management Moderate

    Genetic variant significantly associated with rickets/osteomalacia risk; professional risk stratification warranted

Screening

  • vitamin D level (25-hydroxyvitamin D) Moderate

    rs118066617 CARS2 variant associated with rickets/osteomalacia; vitamin D status is fundamental to bone health

    Check 25-OH vitamin D levels annually; maintain level above 30 ng/mL

Supplements

  • vitamin D3 supplementation Moderate

    Variant association with rickets/osteomalacia indicates benefit of proactive vitamin D repletion

    Consider 1000-4000 IU daily; adjust based on baseline levels and healthcare provider guidance