rs118065693 - CAND1
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections - Unknown journal (n.d.) · Unknown authors · PubMed 28928442
ABSTRACT: Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-associated procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast infections, urinary tract infections, tonsillectomy, childhood ear infections, myringotomy, measles, hepatitis A, rheumatic fever, common colds, rubella and chronic sinus infection, in over 200,000 individuals of European ancestry. We detect 59 genome-wide significant (P < 5 × 10−8) associations in genes with key roles
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic predisposition to chronic sinus infection Moderate
CAND1 variant carries increased sinus infection risk; clinician awareness enables proactive monitoring and earlier diagnosis if symptoms arise
Mention this genetic finding during appointments for respiratory or sinus concerns
Screening
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sinus symptoms given genetic risk Moderate
CAND1 rs118065693 associates with increased chronic sinus infection risk; heightened awareness enables early clinical intervention
Report persistent nasal congestion, facial pressure, or drainage lasting >5 days to healthcare provider