rs118059146 - RAB11B-AS1, ANGPTL4
Magnitude 2.2 · 1 study on file
Reported associations
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Decreased Circulating Very Small Low-Density Lipoprotein is Likely Causal for Age-Related Macular Degeneration - Unknown journal (n.d.) · Unknown authors · PubMed 39091897
ABSTRACT: Objective Abnormal changes in metabolite levels in serum or plasma have been highlighted in several studies in age-related macular degeneration (AMD), the leading cause of irreversible vision loss. Specific changes in lipid profiles are associated with an increased risk of AMD. Metabolites could thus be used to investigate AMD disease mechanisms or incorporated into AMD risk prediction models. However, whether particular metabolites causally affect the disease has yet to be established. Design A 3-tiered analysis of blood metabolites in the United Kingdom (UK) Biobank cohort to identify metabolites that differ in AMD patients with evidence for a putatively causal role in AMD. Participants A total of 72 376 donors from the UK Biobank cohort including participants with AMD (N =
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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lipid panel with VLDL triglyceride percentage Moderate
Genetic variant is strongly associated with higher triglyceride percentage in very small VLDL particles; baseline and periodic assessment establishes phenotype expression
Baseline lipid panel including VLDL triglyceride percentage; repeat every 1-2 years
Diet
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Mediterranean or DASH diet Moderate
VLDL triglyceride levels are modifiable through diet; ANGPTL4 is a key triglyceride metabolism regulator influenced by dietary composition
Emphasize vegetables, fruits, whole grains, lean proteins, and unsaturated fats; limit refined carbohydrates