Expressive

rs11804568 - ATG4C - LINC01739

Magnitude 2.2 · 1 study on file

Reported associations

  • Polygenic architecture and cardiovascular risk of familial combined hyperlipidemia. - Atherosclerosis (2022) · Trinder M, Vikulova D, Pimstone S, Mancini GBJ, Brunham LR · PubMed 34906840

    Familial combined hyperlipidemia (FCHL) is one of the most common inherited lipid phenotypes, characterized by elevated plasma concentrations of apolipoprotein B-100 and triglycerides. The genetic inheritance of FCHL remains poorly understood. The goals of this study were to investigate the polygenetic architecture and cardiovascular risk associated with FCHL. We identified individuals with an FCHL phenotype among 349,222 unrelated participants of European ancestry in the UK Biobank using modified versions of 5 different diagnostic criteria. The prevalence of the FCHL phenotype was 11.44% (n = 39,961), 5.01% (n = 17,485), 1.48% (n = 5,153), 1.10% (n = 3,838), and 0.48% (n = 1,688) according to modified versions of the Consensus Conference, Dutch, Mexico, Brunzell, and Goldstein c

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Saturated fat and trans fats Moderate

    Genetic predisposition to combined hyperlipidemia increases LDL cholesterol response to dietary saturated fat; reduction supports lipid control

    Limit saturated fat to less than 7% of daily calories; minimize trans fats

Discuss with your doctor

  • Familial combined hyperlipidemia risk and family history Moderate

    Variant associated with FCHD; clinical evaluation of personal and family history of lipid disorders or early coronary disease is indicated

    Discuss with primary care provider; assess family history of premature cardiovascular disease or lipid disorders

Exercise

  • Regular aerobic exercise program Moderate

    Physical activity improves HDL cholesterol and triglyceride profiles in individuals with genetic hyperlipidemia predisposition

    150 minutes per week of moderate-intensity aerobic exercise such as brisk walking or cycling

Screening

  • Lipid panel for hyperlipidemia assessment Moderate

    This variant is associated with familial combined hyperlipidemia; lipid testing establishes baseline and phenotype status

    Fasting lipid panel including total cholesterol, LDL, HDL, triglycerides