rs11804386 - LINC02801
Magnitude 2.2 · 1 study on file
Reported associations
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Biological and clinical insights from genetics of insomnia symptoms - Unknown journal (n.d.) · Unknown authors · PubMed 30804566
ABSTRACT: Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we identify 57 loci for self-reported insomnia symptoms in the UK Biobank (n = 453,379) and confirm their impact on self-reported insomnia symptoms in the HUNT study (n = 14,923 cases, 47,610 controls), physician-diagnosed insomnia in Partners Biobank (n = 2,217 cases, 14,240 controls), and accelerometer-derived measures of sleep efficiency and sleep duration in the UK Biobank (n = 83,726). Our results suggest enrichment of genes involved in ubiquitin-mediated proteolysis and of genes expressed in multiple brain regions, skeletal muscle, and adrenal gland. Evidence of
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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Sleep quality and insomnia symptoms Moderate
The rs11804386-A allele increases susceptibility to insomnia symptoms.
Regular sleep quality assessment; seek clinical evaluation if experiencing sleep difficulties.