rs118039683 - GRIP1

Magnitude 2.8 · 1 study on file

Reported associations

• No causal links between estradiol and female's brain and mental health using Mendelian randomization - Unknown journal (n.d.) · Unknown authors · PubMed 41350255

  ABSTRACT: The role of estradiol in depression and Alzheimer's disease - brain disorders that disproportionately affect females - is debated. Results from observational studies are inconsistent and limited by confounding and reverse causation. To overcome these limitations, we perform two-sample Mendelian randomization. We run genome-wide association studies on sex-specific brain age gap, a proxy of brain health, and female-specific estradiol levels using data from the UK Biobank. We test for causal links between genetically-predicted factors related to estradiol exposure (estradiol levels in pre- and postmenopausal samples, reproductive span, age at menarche, age at menopause, number of childbirths) and brain age gap, Alzheimer's disease and depression as outcomes. We replicate our

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