Expressive

rs118039629 - ARL1 - RNU6-1068P

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism. - Diabetes (2022) · Li-Gao R, Hughes DA, van Klinken JB, de Mutsert R, Rosendaal FR, Mook-Kanamori DO, Timpson NJ, Willems van Dijk K · PubMed 34610981

    Humans spend the greater part of the day in a postprandial state. However, the genetic basis of postprandial blood measures is relatively uncharted territory. We examined the genetics of variation in concentrations of postprandial metabolites ( = 150 min) in response to a liquid mixed meal through genome-wide association studies (GWAS) performed in the Netherlands Epidemiology of Obesity (NEO) study ( = 5,705). The metabolite response GWAS identified an association between glucose change and rs10830963:G in the melatonin receptor 1B (β [SE] -0.23 [0.03], = 2.15 × 10 ). In addition, the locus led by rs458741:C showed strong associations with extremely large VLDL (XXLVLDL) particle response (XXLVLDL total cholesterol: β [SE] 0.17 [0.03], = 5.76 × 10 ; XXLVLDL cholesterol ester: β [SE] 0

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • reduce refined carbohydrates and refined grains Moderate

    High postprandial triglycerides are exacerbated by refined carbohydrate intake; reducing these helps moderate meal-related triglyceride response

    Limit refined grains and sugars; replace with whole grains, legumes, and vegetable sources of carbohydrates

Exercise

  • regular aerobic exercise for triglyceride management Moderate

    Aerobic exercise is an established intervention for reducing postprandial triglycerides and improving lipid metabolism

    150 minutes moderate-intensity or 75 minutes vigorous-intensity aerobic activity per week

Screening

  • postprandial triglyceride levels Moderate

    rs118039629-A allele is associated with elevated postprandial triglycerides in intermediate density lipoprotein response

    Check fasting and postprandial triglyceride levels annually or per doctor's guidance