rs118037400 - LINC02055

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association study meta-analysis of suicide death and suicidal behavior - Unknown journal (n.d.) · Unknown authors · PubMed 36253440

    ABSTRACT: Suicide is a worldwide health crisis. We aimed to identify genetic risk variants associated with suicide death and suicidal behavior. Meta-analysis for suicide death was performed using 3765 cases from Utah and matching 6572 controls of European ancestry. Meta-analysis for suicidal behavior using data across five cohorts (n = 8315 cases and 256,478 psychiatric or populational controls of European ancestry) was also performed. One locus in neuroligin 1 (NLGN1) passing the genome-wide significance threshold for suicide death was identified (top SNP rs73182688, with p = 5.48 × 10−8 before and p = 4.55 × 10−8 after mtCOJO analysis conditioning on MDD to remove genetic effects on suicide mediated by MDD). Conditioning on suicidal attempts did not significantl


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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • genetic risk for suicide with healthcare provider Moderate

    Genetic association informs clinical assessment of mental health history and risk stratification

    Bring findings to next health visit

Screening

  • mental health status for suicide risk Moderate

    LINC02055 G allele associated with increased suicide risk in large cohort

    Regular mental health assessments, discuss screening frequency with provider