rs1180331 - PPIEL, PPIEL

Magnitude 4.5 · 1 study on file

Reported associations

• Genetic architecture of sleep in a genome wide association study of device measured sleep traits. - Nature communications (2026) · Portas L, Yuan H, Cai L, Smith-Byrne K, van Duijvenboden S, Kyle SD, Ray D, Howson JM, Doherty A · PubMed 41922918

  Sleep is essential for health and regulated by genetic and environmental factors. We perform genome-wide association studies of device-measured sleep duration, efficiency, and accelerometer-derived rapid eye movement (REM) and non-rapid eye movement (NREM) sleep in 80,013 UK Biobank participants. We identify 20 autosomal loci, 12 of which have not been previously reported, including genome-wide significant associations for REM and NREM sleep duration. MEIS1 shows strong opposing effects on REM and NREM durations and is intolerant to loss-of-function mutations, suggesting an essential role in the regulation of REM/NREM sleep balance. Functional enrichment analysis identifies statistically significant pathways related to chromatin remodelling, lipid metabolism, and metal ion homeostasis whil

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