Expressive

rs118027213 - KTN1-AS1, KTN1

Magnitude 2.2 · 1 study on file

Reported associations

  • Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke - Unknown journal (n.d.) · Unknown authors · PubMed 36240095

    ABSTRACT: Background and Objectives Current genome-wide association studies of ischemic stroke have focused primarily on late-onset disease. As a complement to these studies, we sought to identify the contribution of common genetic variants to risk of early-onset ischemic stroke. Methods We performed a meta-analysis of genome-wide association studies of early-onset stroke (EOS), ages 18-59 years, using individual-level data or summary statistics in 16,730 cases and 599,237 nonstroke controls obtained across 48 different studies. We further compared effect sizes at associated loci between EOS and late-onset stroke (LOS) and compared polygenic risk scores (PRS) for venous thromboembolism (VTE) between EOS and LOS. Results We observed genome-wide significant associations of EOS with 2 varia

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • early-onset stroke risk and preventive strategy Moderate

    rs118027213 is associated with significantly elevated early-onset ischemic stroke risk in a cohort of 615,660 individuals

    Discuss with provider before age 40; develop personalized screening plan

Lifestyle

  • blood pressure control to target <130/80 mmHg Moderate

    Hypertension is the strongest modifiable stroke risk factor; individuals with genetic predisposition benefit from stricter control

    Home BP monitoring monthly, target <130/80 mmHg, discuss medications

Screening

  • cardiovascular screening by age 35 Moderate

    Early detection and management of modifiable stroke risk factors is critical for individuals with genetic predisposition to early-onset stroke

    BP, lipids, ECG, carotid ultrasound; repeat every 2-3 years