rs11802591 - GBP5 - GBP6
Magnitude 2.8 · 2 studies on file
Reported associations
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Metabolome-wide association identifies ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations. - Nature cardiovascular research (2025) · Sadhu N, Dalan R, Jain PR, Lee CJM, Pakkiri LS, Tay KY, Mina TH, Low D, Min Y, Ackers-Johnson M, Thi TT, Kota VG, Shi Y, Liu Y, Yu H, Lai V, Yang Y, Tay D, Ng HK, Wang X, Wong KE, Lam M, Guan XL, Bertin N, Wong E, Best J, Sarangarajan R, Elliott P, Riboli E, Lee J, Lee ES, Ngeow J, Tan P, Cheung C, Drum CL, Foo RS, Michelotti GA, Yu H, Sheridan PA, Loh M, Chambers JC · PubMed 40360795
The burden of cardiovascular disease is rising in the Asia-Pacific region, in contrast to falling cardiovascular disease mortality rates in Europe and North America. Here we perform quantification of 883 metabolites by untargeted mass spectroscopy in 8,124 Asian adults and investigate their relationships with carotid intima media thickness, a marker of atherosclerosis. Plasma concentrations of 3beta-hydroxy-5-cholestenoate (3BH5C), a cholesterol metabolite, were inversely associated with carotid intima media thickness, and Mendelian randomization studies supported a causal relationship between 3BH5C and coronary artery disease. The observed effect size was 5- to 6-fold higher in Asians than Europeans. Colocalization analyses indicated the presence of a shared causal variant between 3BH5C p
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Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study - Unknown journal (n.d.) · Unknown authors · PubMed 38104120
ABSTRACT: Most hypertension-related genome-wide association studies (GWASs) focus on non-African populations, despite hypertension (a major risk factor for cardiovascular disease) being highly prevalent in Africa. The AWI-Gen study GWAS meta-analysis for blood pressure (BP)-related traits (systolic and diastolic BP, pulse pressure, mean-arterial pressure and hypertension) from three sub-Saharan African geographic regions (N = 10,775), identifies two novel genome-wide significant signals (p < 5E-08): systolic BP near P2RY1 (rs77846204; intergenic variant, p = 4.95E-08) and pulse pressure near LINC01256 (rs80141533; intergenic variant, p = 1.76E-08). No genome-wide signals are detected for the AWI-Gen GWAS meta-analysis with previous African-ancestry GWASs (UK Biobank (Africa
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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sodium restriction and potassium-rich diet Moderate
Dietary sodium reduction and increased potassium intake reduce arterial stiffness and pulse pressure, particularly relevant given genetic predisposition
Target less than 2300 mg sodium daily; increase potassium-rich foods such as vegetables, fruits, beans, nuts
Discuss with your doctor
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genetic predisposition to pulse pressure and risk management Moderate
Genetic information allows targeted assessment and early intervention for pulse pressure-related cardiovascular risk before clinical manifestations
Exercise
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regular aerobic exercise for vascular health Moderate
Aerobic exercise improves arterial compliance and endothelial function, directly addressing pulse pressure in those with genetic predisposition
150 minutes moderate-intensity aerobic activity weekly or 75 minutes vigorous intensity
Screening
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pulse pressure and arterial stiffness assessment Moderate
rs11802591 A allele is associated with increased pulse pressure (p=1.0e-6, n=10,772), a marker of arterial stiffness and independent cardiovascular risk
Annual blood pressure and pulse pressure assessment starting at age 40 or if cardiovascular risk factors present