rs118024684 - CYP4F44P - HSPA8P13

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide meta-analysis identifies novel loci associated with free triiodothyronine and thyroid-stimulating hormone. - Journal of endocrinological investigation (2020) · Popović M, Matana A, Torlak V, Boutin T, Brdar D, Gunjača I, Kaličanin D, Kolčić I, Boraska Perica V, Punda A, Polašek O, Barbalić M, Hayward C, Zemunik T · PubMed 30843173

  Thyroid hormones are essential for the normal function of almost all human tissues, and have critical roles in metabolism, differentiation and growth. Free triiodothyronine (fT3), free thyroxine (fT4) and thyroid-stimulating hormone (TSH) levels are under strong genetic influence; however, most of the heritability is yet unexplained. In order to identify novel loci associated with fT3, fT4 and TSH serum levels we performed a genome-wide meta-analysis of 7 411 206 polymorphisms in up to 1731 euthyroid individuals from three Croatian cohorts from Dalmatia region: two genetically isolated island populations and one mainland population. Additionally, we also performed a bivariate analysis of fT3 and fT4 levels. The EPHB2 gene variant rs67142165 reached genome-wide significance for associatio

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