rs118003389 - HGF
Magnitude 4.5 · 1 study on file
Reported associations
-
Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients - Unknown journal (n.d.) · Unknown authors · PubMed 32238385
ABSTRACT: Objectives Genome-wide meta-analyses of clinically defined gout were performed to identify subtype-specific susceptibility loci. Evaluation using selection pressure analysis with these loci was also conducted to investigate genetic risks characteristic of the Japanese population over the last 2000-3000 years. Methods Two genome-wide association studies (GWASs) of 3053 clinically defined gout cases and 4554 controls from Japanese males were performed using the Japonica Array and Illumina Array platforms. About 7.2 million single-nucleotide polymorphisms were meta-analysed after imputation. Patients were then divided into four clinical subtypes (the renal underexcretion type, renal overload type, combined type and normal type), and meta-analyses were conducted in the same manner.
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
-
excessive alcohol Moderate
Alcohol reduces uric acid excretion and increases production; associated with gout flares in susceptible individuals
Limit alcohol consumption, especially beer; consider no more than 1-2 drinks per day
-
high-purine foods Moderate
Purine-rich foods increase uric acid production; limiting them reduces gout flare risk in genetically susceptible individuals
Limit red meat, organ meats, shellfish, and high-fructose beverages
Discuss with your doctor
-
gout risk and prevention strategies Moderate
rs118003389 risk allele is associated with gout susceptibility; personalized assessment and management is recommended
Mention genetic association with gout at next clinical visit
Lifestyle
-
adequate hydration Moderate
Increased fluid intake promotes uric acid excretion through urine, reducing serum urate levels and gout risk
Drink at least 2-3 liters of water daily, more if exercising or in hot climate
Screening
-
serum uric acid level Moderate
HGF rs118003389 risk allele increases gout susceptibility; uric acid monitoring enables early detection and intervention
Baseline serum uric acid measurement, then periodic monitoring as clinically indicated