Expressive

rs11800243 - PCSK9

Magnitude 2.2 · 1 study on file

Reported associations

  • A large electronic health record-based genome-wide study of serum lipids - Unknown journal (n.d.) · Unknown authors · PubMed 29507422

    ABSTRACT: A genome-wide association study of 94,674 multi-ethnic Kaiser Permanente members utilizing 478,866 longitudinal untreated serum lipid electronic-health-record-derived measurements (EHRs) empowered multiple novel findings: 121 new SNP associations (46 primary, 15 conditional, 60 in meta-analysis with Global Lipids Genetic Consortium); increase of 33-42% in variance explained with multiple measurements; sex differences in genetic impact (greater in females for LDL, HDL, TC, the opposite for TG); differences in variance explained amongst non-Hispanic whites, Latinos, African Americans, and East Asians; genetic dominance and epistasis, with strong evidence for both at ABOxFUT2 for LDL; and eQTL tissue-enrichment implicating the liver, adipose, and pancreas. Utilizing EHR pharmacy dat

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • LDL cholesterol level Moderate

    rs11800243 G allele associated with increased LDL cholesterol levels

    Establish baseline, then monitor annually

Diet

  • saturated fat Moderate

    Saturated fat elevates LDL; reduction is first-line for elevated LDL in G allele carriers

    Limit to less than 7% of daily caloric intake

  • soluble dietary fiber Moderate

    Soluble fiber reduces LDL cholesterol absorption in individuals with elevated LDL

    Target 10-25g daily from oats, legumes, fruits

Discuss with your doctor

  • PCSK9 inhibitor therapy Moderate

    PCSK9 inhibitors directly target the LDL receptor pathway dysregulated in rs11800243 G allele carriers

Exercise

  • aerobic exercise Moderate

    Regular aerobic activity reduces LDL and improves cardiovascular outcomes in high-LDL states

    150 minutes per week of moderate-intensity aerobic activity