rs118002214 - NOB1
Magnitude 4.5 · 1 study on file
Reported associations
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Dyslipidaemia-Genotype Interactions with Nutrient Intake and Cerebro-Cardiovascular Disease - Unknown journal (n.d.) · Unknown authors · PubMed 35884923
ABSTRACT: A comprehensive understanding of gene-diet interactions is necessary to establish proper dietary guidelines to prevent and manage cardio-cerebrovascular disease (CCD). We investigated the role of genetic variants associated with dyslipidaemia (DL) and their interactions with macro-nutrients for cardiovascular disease using a large-scale genome-wide association study of Korean adults. A total of 58,701 participants from a Korean genome and epidemiology study were included. Their dietary intake was assessed using a food frequency questionnaire. Dyslipidaemia was defined as total cholesterol (TCHL) ≥ 240 mg/dL, high-density lipoprotein (HDL) < 40 mg/dL, low-density lipoprotein (LDL) ≥ 160 mg/dL, triglycerides (TG) ≥ 200 mg/dL, or dyslipidaemia history. Their nutrient intake wa
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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fatty fish and omega-3 rich foods Moderate
Omega-3 fatty acids reduce triglyceride synthesis and improve clearance, counteracting genetic predisposition to elevated triglycerides.
Consume fatty fish (salmon, mackerel, sardines) 2 or more times per week
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refined carbohydrates and added sugars Moderate
Refined carbohydrates increase hepatic triglyceride synthesis; limiting intake is important for genetic predisposition to elevated triglycerides.
Limit refined carbs and added sugars to less than 25 percent of daily calories
Discuss with your doctor
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elevated triglyceride genetic risk and management Moderate
Genetic association warrants professional assessment to determine if lifestyle modifications are sufficient or if pharmacotherapy is indicated.
Raise with provider; especially if fasting triglycerides exceed 150 mg/dL
Exercise
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regular aerobic exercise Moderate
Aerobic exercise enhances triglyceride clearance via lipoprotein lipase activation and improves insulin sensitivity.
150 minutes moderate-intensity or 75 minutes vigorous aerobic exercise weekly
Screening
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fasting triglyceride and lipid panel Moderate
NOB1 rs118002214 C-allele is associated with elevated triglyceride levels; direct measurement assesses manifestation of genetic predisposition.
Fasting lipid panel annually, or more frequently if baseline elevated
Supplements
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fish oil or omega-3 supplement Moderate
Concentrated omega-3 supplementation reduces triglycerides complementary to dietary intake, supporting management of genetic predisposition.
2 to 3 grams daily EPA plus DHA with food, or as directed by healthcare provider