rs117979484 - NPAP1P6 - LINC01507

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association study of early-stage non-small cell lung cancer prognosis: a pooled analysis in the International Lung Cancer Consortium. - Carcinogenesis (2025) · Dong M, Thakral A, Byrne KS, Bosse Y, Zhou H, Zhang Y, Atkins J, Haycock P, Brown MC, Murison K, Timens W, Sin DD, Kothari J, Gabriel AAG, Zaridze D, Savic M, Lissowska J, Świątkowska B, Janout V, Holcatova I, Mukeria A, Fernandez-Tardon G, Davies MPA, Triplette M, Schabath MB, Andrew AS, Chen C, Taylor F, Field JK, Tardon A, Shete SS, Brennan P, Landi MT, McKay J, Amos CI, Lin X, Christiani DC, Hung RJ, Liu G, Xu W · PubMed 40746155

  Lung cancer is the leading cause of cancer mortality. To investigate genetic determinants for prognosis among patients diagnosed with early-stage non-small cell lung cancer (NSCLC), we conducted the first large-scale genome-wide association prognostic study using data from the International Lung Cancer Consortium (ILCCO) through a two-phase analysis. Phase 1 includes the discovery of genome-wide association studies analysis using a multivariable Cox PH model on 3428 NSCLC patients of European ancestry from 10 ILCCO participating studies to identify genetic variants associated with overall survival and validation analysis for genome-wide significant variants (P-value ≤5 × 10-8) using the Cancer Genome Atlas (TCGA). Phase 2 aims to identify causal variants using functional analyses of gen

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