rs117960705 - ACACB

Magnitude 4.5 · 1 study on file

Reported associations

• Genetic variation in cervical preinvasive and invasive disease: a genome-wide association study - Unknown journal (n.d.) · Unknown authors · PubMed 33794208

  ABSTRACT: Summary Background Most uterine cervical high-risk human papillomavirus (HPV) infections are transient, with only a small fraction developing into cervical cancer. Family aggregation studies and heritability estimates suggest a significant inherited genetic component. Candidate gene studies and previous genome-wide association studies (GWASs) report associations between the HLA region and cervical cancer. Adopting a genome-wide approach, we aimed to compare genetic variation in women with invasive cervical cancer and cervical intraepithelial neoplasia (CIN) grade 3 with that in healthy controls. Methods We did a GWAS in a cohort of unrelated European individuals using data from UK Biobank, a population-based cohort including 273 377 women aged 40-69 years at recruitment betwe

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