rs117944720 - PRKN

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide association study (GWAS) of human host factors influencing viral severity of herpes simplex virus type 2 (HSV-2) - Genes and immunity (2019) · Kleinstein SE, Shea PR, Allen AS, Koelle DM, Wald A, Goldstein DB · PubMed 29535370

  ABSTRACT: Herpes simplex virus type 2 (HSV-2) is an incurable viral infection with severity ranging from asymptomatic to frequent recurrences. The viral shedding rate has been shown as a reproducible HSV-2 severity endpoint that correlates with lesion rates. We used a genome-wide association study (GWAS) to investigate the role of common human genetic variation in HSV-2 severity. We performed a GWAS on 223 HSV-2-positive participants of European ancestry. Severity was measured by viral shedding rate, as defined by the percent of days PCR+ for HSV-2 DNA over at least 30 days. Analyses were performed under linear regression models, adjusted for age, sex, and ancestry. There were no genome-wide significant (p<5E-08) associations with HSV-2 viral shedding rate. The top non-significant SNP (rs7

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