rs117915310 - PSTK

Magnitude 4.5 · 1 study on file

Reported associations

• A genome-wide association study on low susceptibility to hepatitis C virus infection (GEHEP012 study). - Liver international : official journal of the International Association for the Study of the Liver (2020) · Real LM, Fernández-Fuertes M, Sáez ME, Rivero-Juárez A, Frías M, Téllez F, Santos J, Merino D, Moreno-Grau S, Gómez-Salgado J, González-Serna A, Corma-Gómez A, Ruiz A, Macías J, Pineda JA · PubMed 31206233

  A low proportion of individuals repeatedly exposed to the hepatitis C virus (HCV) remain uninfected. This condition could have a genetic basis but it is not known whether or not it is mainly driven by a high-penetrance common allele. To explore whether low susceptibility to HCV infection is mainly driven by a high-penetrance common allele. In this genome-wide association study (GWAS), a total of 804 HCV-seropositive individuals and 27 high-risk HCV-seronegative (HRSN) subjects were included. Plink and Magma software were used to carry out single nucleotide polymorphism (SNP)-based and gene-based association analyses respectively. No SNP nor any gene was associated with low susceptibility to HCV infection after multiple testing correction. However, SNPs previously associated with this trait

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