rs117911063 - CDC42BPB
Magnitude 2.2 · 2 studies on file
Reported associations
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A scalable variational inference approach for increased mixed-model association power - Unknown journal (n.d.) · Unknown authors · PubMed 39789286
ABSTRACT: The rapid growth of modern biobanks is creating new opportunities for large-scale genome-wide association studies (GWASs) and the analysis of complex traits. However, performing GWASs on millions of samples often leads to trade-offs between computational efficiency and statistical power, reducing the benefits of large-scale data collection efforts. We developed Quickdraws, a method that increases association power in quantitative and binary traits without sacrificing computational efficiency, leveraging a spike-and-slab prior on variant effects, stochastic variational inference and graphics processing unit acceleration. We applied Quickdraws to 79 quantitative and 50 binary traits in 405,088 UK Biobank samples, identifying 4.97% and 3.25% more associations than REGENIE and 22.71%
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Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways - Unknown journal (n.d.) · Unknown authors · PubMed 29662059
ABSTRACT: Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which have progressively increased in number with increasing sample sizes of the respective studies. Here, we conduct a genome-wide association study in 322,580 UK Biobank participants for three depression-related phenotypes: broad depression, probable major depressive disorder (MDD), and International Classification of Diseases (ICD, version 9 or 10)-coded MDD. We identify 17 independent loci that are significantly associated (P < 5 × 10−8) across the three phenotypes. The direction of effect of these loci is consistently replicated in an independent sample, with 14 loci likely representing novel findings. Gene sets are enriched in
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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gamma-glutamyltransferase (GGT) levels Moderate
Genetic variant rs117911063 T-allele associates with elevated GGT, an oxidative stress marker linked to liver and metabolic health outcomes.
Annual GGT measurement; discuss rising trends with physician
Screening
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depression screening Moderate
Genetic variant rs117911063 T-allele associates with increased major depressive disorder risk in large population cohorts.
Annual depression screening (e.g., PHQ-9); discuss with healthcare provider