Expressive

rs117906172 - ATXN1L

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484

    ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • reduce saturated fat intake Moderate

    Genetic predisposition to elevated cholesterol responds to dietary saturated fat reduction

    Limit saturated fat to less than 7% of daily calories

Discuss with your doctor

  • genetic predisposition to elevated cholesterol Moderate

    rs117906172 G allele is associated with elevated total cholesterol based on large GWAS meta-analysis

    Discuss personalized cholesterol management strategy

Exercise

  • regular aerobic exercise Moderate

    Physical activity effectively lowers cholesterol in genetically predisposed individuals

    150 minutes moderate-intensity aerobic exercise per week

Screening

  • lipid panel and total cholesterol Moderate

    rs117906172 G allele carriers have elevated total cholesterol levels through PHLPP2 expression changes in metabolic tissues

    Lipid panel check every 1-2 years