rs117898573 - LRP1B

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic associations with healthy ageing among Chinese adults - Unknown journal (n.d.) · Unknown authors · PubMed 35927272

  ABSTRACT: The genetic basis of overall healthy ageing, especially among the East-Asian population is understudied. We conducted a genome-wide association study among 1618 Singapore Chinese elderly participants (65 years or older) ascertained to have aged healthily and compared their genome-wide genotypes to 6221 participants who did not age healthily, after a 20-year follow-up. Two genetic variants were identified (PMeta < 2.59 × 10−8) to be associated with healthy aging, including the LRP1B locus previously associated in long-lived individuals without cognitive decline. Our study sheds additional insights on the genetic basis of healthy ageing. FULL TEXT: [INTRO] Human life expectancy has increased remarkably over the last two centuries, however, this is often not translated a

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