rs117866409 - LINC02305 - MTND4P33

Magnitude 2.2 · 1 study on file

Reported associations

• Sex-Specific Causal Relations between Steroid Hormones and Obesity-A Mendelian Randomization Study - Unknown journal (n.d.) · Unknown authors · PubMed 34822396

  ABSTRACT: Steroid hormones act as important regulators of physiological processes including gene expression. They provide possible mechanistic explanations of observed sex-dimorphisms in obesity and coronary artery disease (CAD). Here, we aim to unravel causal relationships between steroid hormones, obesity, and CAD in a sex-specific manner. In genome-wide meta-analyses of four steroid hormone levels and one hormone ratio, we identified 17 genome-wide significant loci of which 11 were novel. Among loci, seven were female-specific, four male-specific, and one was sex-related (stronger effects in females). As one of the loci was the human leukocyte antigen (HLA) region, we analyzed HLA allele counts and found four HLA subtypes linked to 17-OH-progesterone (17-OHP), including HLA-B1402. Usi

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