rs11784654 - ERI1
Magnitude 2.2 · 2 studies on file
Reported associations
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GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer - Unknown journal (n.d.) · Unknown authors · PubMed 34021172
ABSTRACT: Genetic studies have examined body-shape measures adjusted for body mass index (BMI), while allometric indices are additionally adjusted for height. We performed the first genome-wide association study of A Body Shape Index (ABSI), Hip Index (HI) and the new Waist-to-Hip Index and compared these with traditional indices, using data from the UK Biobank Resource for 219,872 women and 186,825 men with white British ancestry and Bayesian linear mixed-models (BOLT-LMM). One to two thirds of the loci identified for allometric body-shape indices were novel. Most prominent was rs72959041 variant in RSPO3 gene, expressed in visceral adipose tissue and regulating adrenal cell renewal. Highly ranked were genes related to morphogenesis and organogenesis, previously additionally linked to can
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Genomics and phenomics of body mass index reveals a complex disease network - Unknown journal (n.d.) · Unknown authors · PubMed 36581621
ABSTRACT: Elevated body mass index (BMI) is heritable and associated with many health conditions that impact morbidity and mortality. The study of the genetic association of BMI across a broad range of common disease conditions offers the opportunity to extend current knowledge regarding the breadth and depth of adiposity-related diseases. We identify 906 (364 novel) and 41 (6 novel) genome-wide significant loci for BMI among participants of European (N~1.1 million) and African (N~100,000) ancestry, respectively. Using a BMI genetic risk score including 2446 variants, 316 diagnoses are associated in the Million Veteran Program, with 96.5% showing increased risk. A co-morbidity network analysis reveals seven disease communities containing multiple interconnected diseases associated with BMI
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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body mass index and weight Moderate
rs11784654 T allele carriers show genetic predisposition to higher body mass index, an obesity-related metabolic and cardiovascular risk factor.
Quarterly weight monitoring; discuss management targets with physician.
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waist-to-hip ratio Moderate
rs11784654 A allele carriers have increased genetic predisposition to unfavorable waist-hip ratio, a cardiovascular and metabolic risk factor.
Annual measurement of waist and hip circumference; discuss results with physician.