rs117835232 - CDKAL1

Magnitude 4.5 · 1 study on file

Reported associations

• Novel association between CDKAL1 and cholesterol efflux capacity: Replication after GWAS-based discovery. - Atherosclerosis (2019) · Cheon EJ, Cha DH, Cho SK, Noh HM, Park S, Kang SM, Gee HY, Lee SH · PubMed 29674289

  Although the importance of the functional properties of high-density lipoprotein (HDL) has been increasingly emphasized, studies on the genetic factors associated with HDL function are highly limited. The aim of this study was to identify genetic variants associated with an individual's cholesterol efflux capacity (CEC) using a genome-wide association study approach. This study included a discovery group of 607 subjects with coronary artery disease and an independent replication group of 158 subjects. CEC was assessed using a radioisotope and ApoB-depleted serum. Genome-wide associations between the adjusted CEC and genotyped and imputed variants were examined with linear regression, assuming an additive genetic model. Finally, adjustments were made for confounding parameters to assess the

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