rs117831057 - AP1M2 - LSM2P1
Magnitude 4.5 · 1 study on file
Reported associations
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Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration - Unknown journal (n.d.) · Unknown authors · PubMed 31719535
ABSTRACT: Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lip
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Sleep duration and LDL cholesterol interaction Moderate
This SNP shows a highly significant interaction between sleep duration and LDL cholesterol (p=3e-21, n=61548), suggesting variant carriers may be especially sensitive to sleep deprivation effects on lipid metabolism
Maintain 7-9 hour sleep duration; monitor LDL annually, especially if sleep is typically <7 hours