rs11782313 - PTK2
Magnitude 4.5 · 1 study on file
Reported associations
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A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype - Unknown journal (n.d.) · Unknown authors · PubMed 35872910
ABSTRACT: Background Occult atrial fibrillation (AF) is one of the major causes of embolic stroke of undetermined source (ESUS). Knowing the underlying etiology of an ESUS will reduce stroke recurrence and/or unnecessary use of anticoagulants. Understanding cardioembolic strokes (CES), whose main cause is AF, will provide tools to select patients who would benefit from anticoagulants among those with ESUS or AF. We aimed to discover novel loci associated with CES and create a polygenetic risk score (PRS) for a more efficient CES risk stratification. Methods Multitrait analysis of GWAS (MTAG) was performed with MEGASTROKE-CES cohort (n = 362,661) and AF cohort (n = 1,030,836). We considered significant variants and replicated those variants with MTAG p-value < 5 × 10−8 influencing both t
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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Comprehensive cardiovascular and cardiac rhythm evaluation Moderate
PTK2 T-allele increases cardioembolic stroke risk predominantly via atrial fibrillation and cardiac conduction pathways identified in GWAS-MTAG analysis.
Discuss with your doctor about ECG, AF screening (Holter or event monitoring), and cardiac disease assessment.