Expressive

rs117816992 - SLC2A6 - MYMK

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections - Unknown journal (n.d.) · Unknown authors · PubMed 28928442

    ABSTRACT: Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-associated procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast infections, urinary tract infections, tonsillectomy, childhood ear infections, myringotomy, measles, hepatitis A, rheumatic fever, common colds, rubella and chronic sinus infection, in over 200,000 individuals of European ancestry. We detect 59 genome-wide significant (P < 5 × 10−8) associations in genes with key roles

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • regular aerobic exercise for respiratory fitness Moderate

    Good cardiovascular and respiratory fitness may reduce pneumonia severity and risk

    Engage in moderate aerobic exercise at least 150 minutes weekly

Lifestyle

  • air pollution and respiratory irritants Moderate

    Environmental risk factors for pneumonia are particularly relevant given genetic predisposition

    Minimize exposure to air pollution and use appropriate respiratory protection when needed

  • tobacco smoking Moderate

    Smoking is a major risk factor for pneumonia; particularly important given genetic predisposition

    Avoid all tobacco products; if currently smoking, prioritize cessation

Screening

  • pneumococcal vaccination strategy Moderate

    rs117816992 is associated with increased pneumonia susceptibility; vaccines protect against major pneumonia pathogens

    Discuss pneumococcal vaccination (PCV13 and/or PPSV23) timing and need with healthcare provider