rs11781551 - MRPS36P3 - SMILR

Magnitude 2.2 · 1 study on file

Reported associations

• Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque - Unknown journal (n.d.) · Unknown authors · PubMed 21909108

  [INTRO] Coronary heart disease (CHD) and stroke rank among the leading causes of death in the industrialized world and a significant genetic component underlies both outcomes. These clinical events are often preceded by the development of subclinical atherosclerosis, typically a thickening of the artery wall due to deposition of cholesterol rich material in the arteries that supply blood to major organs. Generalized atherosclerosis results from endothelial dysfunction, inflammation, abnormalities in lipoprotein metabolism , coagulation and fibrinolysis. [INTRO] Measures of subclinical atherosclerosis, disease that occurs before symptoms are noted, are predictive of incident clinical events and can be detected non-invasively and with reasonable precision in population samples using high r

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