rs11781321 - ATP6V0D2
Magnitude 2.2 · 1 study on file
Reported associations
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Genetically regulated gene expression underlies lipid traits in Hispanic cohorts - Unknown journal (n.d.) · Unknown authors · PubMed 31393916
ABSTRACT: Plasma lipid levels are risk factors for cardiovascular disease, a leading cause of death worldwide. While many studies have been conducted in genetic variation underlying lipid levels, they mainly comprise individuals of European ancestry and thus their transferability to non-European populations is unclear. We performed genome-wide (GWAS) and imputed transcriptome-wide association studies of four lipid traits in the Hispanic Community Health Study/Study of Latinos cohort (HCHS/SoL, n = 11,103), replicated top hits in the Multi-Ethnic Study of Atherosclerosis (MESA, n = 3,855), and compared the results to the larger, predominantly European ancestry meta-analysis by the Global Lipids Genetics Consortium (GLGC, n = 196,475). In our GWAS, we found significant SNP associations in re
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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baseline and periodic lipid panel Moderate
rs11781321 carries strong GWAS association with elevated total cholesterol
obtain baseline lipid panel, repeat per provider guidance or every 1-3 years
Discuss with your doctor
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cholesterol management strategy Moderate
rs11781321 carries strong GWAS association with elevated total cholesterol
discuss diet, exercise, and medication options for cholesterol control