rs117807585 - SORL1

Magnitude 2.0 · 1 study on file

Reported associations

• Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease - Unknown journal (n.d.) · Unknown authors · PubMed 37198259

  ABSTRACT: Genome-wide association studies (GWAS) of Alzheimer's disease are predominantly carried out in European ancestry individuals despite the known variation in genetic architecture and disease prevalence across global populations. We leveraged published GWAS summary statistics from European, East Asian, and African American populations, and an additional GWAS from a Caribbean Hispanic population using previously reported genotype data to perform the largest multi-ancestry GWAS meta-analysis of Alzheimer's disease and related dementias to date. This method allowed us to identify two independent novel disease-associated loci on chromosome 3. We also leveraged diverse haplotype structures to fine-map nine loci with a posterior probability >0.8 and globally assessed the heterogeneity

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