rs11780002 - DLC1 - SGCZ
Magnitude 2.2 · 1 study on file
Reported associations
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Large-scale genome-wide association study of coronary artery disease in genetically diverse populations - Unknown journal (n.d.) · Unknown authors · PubMed 35915156
ABSTRACT: We report a genome-wide association study (GWAS) of coronary artery disease (CAD) incorporating nearly a quarter million cases, in which existing studies are integrated with data from cohorts of White, Black, and Hispanic individuals from the Million Veteran Program. We document near equivalent heritability of CAD across multiple ancestral groups, identify 95 novel loci, including the first nine to be identified on the X-chromosome, detect the first eight genome-wide significant loci among Blacks and Hispanics, and demonstrate that two common haplotypes at the 9p21 locus are responsible for risk stratification in all populations except those of African origin, where these haplotypes are virtually absent. Moreover, in the largest GWAS for angiographically derived coronary atherosc
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic risk for coronary artery disease Moderate
rs11780002 associated with increased coronary artery disease risk in large GWAS
Discuss baseline CAD risk, family history, and preventive strategy with primary care or cardiologist
Screening
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Lipid profile and blood pressure monitoring Moderate
Standard screening for individuals with elevated coronary artery disease genetic risk
Annual lipid panel and blood pressure check, baseline EKG based on age and risk