Expressive

rs11779860 - LAPTM4B

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization - Unknown journal (n.d.) · Unknown authors · PubMed 24952745

    ABSTRACT: The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal Mendelian Long QT Syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals we identified 35 common variant QT interval loci, that collectively explain ∼8-10% of QT variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 novel QT loci in 298 unrelated LQTS probands identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode for protei

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • QT interval risk and drug interactions with cardiologist Moderate

    rs11779860 C-allele associates with QT prolongation, and QT-prolonging drugs increase arrhythmia risk

    Schedule cardiology consultation to review baseline QT interval and medication safety

Drug interactions

  • QT-prolonging medications and supplements with pharmacist Moderate

    This variant prolongs baseline QT interval, compounding arrhythmia risk from QT-prolonging medications

    Review all medications and supplements for QT-prolonging potential before initiating new drugs

Screening

  • baseline ECG and QT interval measurement Moderate

    rs11779860 C-allele associates with prolonged QT interval, increasing cardiac arrhythmia risk

    Obtain ECG at baseline, repeat as advised by cardiologist