rs11779572 - CDCA2 - EBF2
Magnitude 2.2 · 1 study on file
Reported associations
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Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107
Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Chronic straining from constipation or respiratory strain Moderate
Chronic increased intra-abdominal pressure from constipation or coughing increases hernia risk in genetically predisposed individuals.
Manage constipation with adequate fiber, hydration, and exercise; seek treatment for chronic cough.
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Heavy lifting and repetitive abdominal strain Moderate
Increased intra-abdominal pressure is a risk factor for hernia; genetic predisposition amplifies this mechanical risk.
Limit lifting to less than 25 lbs for repetitive tasks; use proper lifting technique.
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Maintain healthy body weight Moderate
Excess abdominal weight increases intra-abdominal pressure and hernia risk; effect is likely amplified in genetically predisposed individuals.
Target BMI 18.5-24.9 kg/m2; consult physician for personalized goals.
Screening
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Clinical screening for inguinal hernia Moderate
G allele at rs11779572 is associated with increased inguinal hernia risk; baseline and periodic clinical assessment enables early detection.
Baseline abdominal/groin examination; discuss screening intervals with physician.