rs117780640 - TSPYL5 - SNORD3H

Magnitude 2.8 · 1 study on file

Reported associations

• Interrogating the genetic determinants of Tourette syndrome and other tic disorders through genome-wide association studies - Unknown journal (n.d.) · Unknown authors · PubMed 30818990

  ABSTRACT: Objective: Tourette Syndrome is polygenic and highly heritable. Genome-wide association (GWAS) approaches are useful for interrogating the genetic architecture and determinants of Tourette syndrome and other tic disorders. Method: GWAS meta-analysis, gene-based association, and genetic enrichment analyses were conducted in 4,819 Tourette syndrome cases and 9,488 controls. Replication of top loci was conducted in an independent, population-based sample (706 cases; 6,068 controls). Relationships between Tourette polygenic risk scores (PRS), other tic disorders, ascertainment, and tic severity were examined. Results: GWAS and gene-based analyses identified one genome-wide significant locus within FLT3 on chromosome 13, rs2504235 (SNP p=2.1×10−8; Gene p=8.9×10−7), though this a

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.