rs11777810 - WWP1
Magnitude 2.2 · 1 study on file
Reported associations
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Large-scale cross-ancestry genome-wide meta-analysis of serum urate - Unknown journal (n.d.) · Unknown authors · PubMed 38658550
ABSTRACT: Hyperuricemia is an essential causal risk factor for gout and is associated with cardiometabolic diseases. Given the limited contribution of East Asian ancestry to genome-wide association studies of serum urate, the genetic architecture of serum urate requires exploration. A large-scale cross-ancestry genome-wide association meta-analysis of 1,029,323 individuals and ancestry-specific meta-analysis identifies a total of 351 loci, including 17 previously unreported loci. The genetic architecture of serum urate control is similar between European and East Asian populations. A transcriptome-wide association study, enrichment analysis, and colocalization analysis in relevant tissues identify candidate serum urate-associated genes, including CTBP1, SKIV2L, and WWP2. A phenome-wide ass
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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serum urate levels Moderate
WWP1 variant associated with higher serum uric acid; baseline and periodic monitoring enables early detection of elevated levels
Annual serum urate testing; more frequent if elevated
Diet
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high-purine foods (organ meats, anchovies, sardines) Moderate
Purines are metabolized to uric acid; dietary reduction helps manage serum urate levels in genetically predisposed individuals
Limit organ meats and high-purine seafood; emphasize vegetables, dairy, plant proteins
Discuss with your doctor
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genetic risk for elevated uric acid and gout prevention Moderate
Genetic predisposition increases gout risk; early intervention can prevent acute attacks and long-term complications
Lifestyle
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adequate hydration for uric acid clearance Moderate
Increased urine flow enhances renal excretion of uric acid; hydration is particularly important for individuals with elevated serum urate
Maintain intake of 2-3 liters water daily; adjust for activity and climate