Expressive

rs11777102 - CDCA2 - EBF2

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107

    Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Inguinal hernia risk assessment and prevention strategies Moderate

    Genetic predisposition (OR 1.09) warrants personalized risk counseling and prevention planning.

Lifestyle

  • Heavy lifting and strenuous abdominal straining Moderate

    Abdominal wall stress combined with genetic predisposition significantly increases hernia development risk.

    Use proper lifting technique; avoid lifting >50 lbs without core support

  • Maintain healthy body weight Moderate

    Obesity increases intra-abdominal pressure, exacerbating genetic predisposition to hernia.

    Maintain BMI 18.5-25; discuss exercise and diet plan with doctor

Screening

  • Inguinal hernia clinical examination Moderate

    Genetic predisposition increases hernia risk; baseline assessment identifies existing or at-risk status.

    Discuss screening timing with doctor; consider ultrasound if symptoms develop