Expressive

rs117763955 - ADGRB3

Magnitude 4.5 · 1 study on file

Reported associations

  • Interaction of environmental factors with the polygenic risk scores of thinness-related genes in preventing obesity risk in middle-aged adults: The KoGES. - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association (2023) · Zhou JY, Liu M, Park S · PubMed 36632775

    Some persons are genetically resistant to obesity, but only a few studies have evaluated thinness genes for preventing obesity. We aimed to investigate the association of polygenic variants with being underweight and their interaction with the lifestyles of middle-aged and elderly persons and identify potential new genetic approaches for managing body weight. In total, 58,701 participants aged 40-77 years were recruited from urban hospitals in Korea. Underweight (case) was defined as body mass index (BMI) < 18.5 kg m (n = 991) and normal weight (control, n = 21,921) was defined as 18.5 ≤ BMI < 23 kg m . A genome-wide association study was run to identify thinness-related single nucleotide polymorphisms (SNPs) after adjustment for compound factors using Gplink. The gen

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • calorie and nutrient-dense foods Moderate

    Genetic predisposition to underweight may require intentional optimization of caloric and nutritional intake

    Coordinate with healthcare provider on appropriate caloric targets and meal frequency

Discuss with your doctor

  • personalized weight management and nutrition strategy Moderate

    Genetic risk for underweight benefits from medical guidance on appropriate interventions for individual circumstances

Screening

  • weight and BMI Moderate

    rs117763955 T allele is significantly associated with underweight phenotype, warranting regular monitoring

    Annual BMI assessment; more frequent screening if BMI below 18.5