rs117762284 - IYD - PLEKHG1
Magnitude 4.5 · 1 study on file
Reported associations
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Extended genome‐wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry - Unknown journal (n.d.) · Unknown authors · PubMed 38958117
ABSTRACT: Abstract INTRODUCTION Despite a two‐fold risk, individuals of African ancestry have been underrepresented in Alzheimer's disease (AD) genomics efforts. METHODS Genome‐wide association studies (GWAS) of 2,903 AD cases and 6,265 controls of African ancestry. Within‐dataset results were meta‐analyzed, followed by functional genomics analyses. RESULTS A novel AD‐risk locus was identified in MPDZ on chromosome (chr) 9p23 (rs141610415, MAF = 0.002, p = 3.68×10−9). Two additional novel common and nine rare loci were identified with suggestive associations (P < 9×10−7). Comparison of association and linkage disequilibrium (LD) patterns between datasets with higher and lower degrees of African ancestry showed differential association patterns at chr12q23.2 (ASCL1), s
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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blood pressure screening and management Moderate
PLEKHG1 encodes a Rho GTPase signaling protein associated with blood pressure regulation and white matter hyperintensities; hypertension is a modifiable Alzheimer's disease risk factor
annual blood pressure measurement; maintain systolic < 130 mmHg per hypertension guidelines
Screening
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neuropsychological assessment for early cognitive changes Moderate
rs117762284 is associated with increased Alzheimer's disease risk (p=4.21e-7) in individuals of African ancestry; early detection enables timely intervention
baseline assessment starting at age 55-60; repeat every 2-3 years