rs117761895 - PLXNA1 - PRR23E
Magnitude 4.5 · 1 study on file
Reported associations
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Genetic association study identifies genetic variants for non-alcoholic fatty liver without comorbidities in the Korean population. - Genes & genomics (2023) · Kim YJ, Cho YS · PubMed 37133724
Non-alcoholic fatty liver (NAFL) refers to a disease in which fat builds up in the liver, similar to what occurs for those who drink a lot of alcohol, even in cases of not drinking alcohol at all or only in a small amount. Along with non-alcoholic steatohepatitis (NASH), NAFL is a type of non-alcoholic fatty liver disease (NAFLD). Currently, the prevalence of NAFLD is increasing worldwide. A wide range of comorbidities that can increase the risk of NAFLD includes obesity, type 2 diabetes, dyslipidemia, and metabolic syndrome. This study aimed to discover genetic variants for NAFL in the Korean population. Differing from previous studies, we conducted a genome-wide association study for NAFL in the selected subjects without comorbidities to rule out bias due to the inclusion of confounding
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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NAFLD genetic risk and prevention strategies Moderate
Genetic risk for NAFLD requires discussion with healthcare provider to optimize prevention and monitoring strategies.
Review genetic results and discuss NAFLD screening timeline, lifestyle factors, and when to consider further evaluation
Screening
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Baseline liver assessment for NAFLD Moderate
PLXNA1 risk allele T is associated with 1.94-fold increased NAFLD risk; baseline imaging identifies existing disease.
Baseline ultrasound or elastography; repeat every 1-3 years if metabolic risk factors present