rs117759611 - TTC7B
Magnitude 2.2 · 1 study on file
Reported associations
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Detailed stratified GWAS analysis for severe COVID-19 in four European populations - Unknown journal (n.d.) · Unknown authors · PubMed 35848942
ABSTRACT: Abstract Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~0.9-Mb inversion polymorphism that creates two highl
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic predisposition to severe COVID-19 infection outcomes Moderate
Presence of TTC7B rs117759611 risk variant may warrant personalized risk assessment and prevention strategy.
Screening
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Enhanced COVID-19 prevention and monitoring Moderate
TTC7B rs117759611 T allele associates with 1.38x increased risk of severe COVID-19 respiratory failure (GWAS n=14137, p<1e-6), suggesting genetic susceptibility to severe pulmonary disease.
Ensure current vaccination and booster status; seek early medical care for respiratory symptoms if infected