Expressive

rs11775358 - CDCA2

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107

    Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • hernia risk and prevention strategies Moderate

    Genetic variant significantly increases inguinal hernia risk; clinical guidance optimizes prevention and early management

Lifestyle

  • body weight and BMI Moderate

    Variant increases hernia risk; obesity elevates intra-abdominal pressure

    Maintain BMI <25; pursue weight loss if overweight

  • bowel regularity and constipation Moderate

    Variant increases hernia risk; straining during bowel movements raises intra-abdominal pressure

    Consume 25-30g fiber daily; maintain adequate hydration; use stool softeners if needed

  • heavy lifting and strenuous activities Moderate

    Variant increases inguinal hernia risk; lifting and straining raise intra-abdominal pressure

    Limit lifting to <25 lbs; use proper technique and ask for assistance

Screening

  • groin symptoms and bulging Moderate

    Genetic risk increases hernia likelihood; early detection permits elective rather than emergency intervention

    Seek medical evaluation if groin pain, bulge, or discomfort develops